Title: High Prevalence of BRCA1 and BRCA2 Germline Mutations With Loss of Heterozygosity In a Series of Resected Pancreatic Adenocarcinoma and Other Neoplastic Lesions. Authors and Affiliations:
نویسندگان
چکیده
1. Icahn School of Medicine at Mount Sinai, Henry D. Janowitz Division of Gastroenterology, New York, New York 2. Muzzi Mirza Pancreatic Cancer Prevention and Genetics Program, New York, New York 3. Ohio State University, Department of Molecular & Cellular Biochemistry, Columbus, Ohio 4. Columbia University School of Medicine, Division of Digestive and Liver Diseases, New York, New York 5. Stanford University School of Medicine, Division of Gastroenterology and Hepatology, Palo Alto, California 6. Keck School of Medicine at the University of Southern California, Division of Gastroenterology and Liver Diseases, Los Angeles, California 7. Columbia University School of Medicine, Department of Pediatrics and Medicine, New York, New York 8. Columbia University School of Medicine, Department of Surgery, New York, New York 9. Columbia University School of Medicine, Department of Pathology, New York, New York
منابع مشابه
High prevalence of BRCA1 and BRCA2 germline mutations with loss of heterozygosity in a series of resected pancreatic adenocarcinoma and other neoplastic lesions.
PURPOSE Pancreatic ductal adenocarcinoma (PDAC) is associated with the breast ovarian cancer syndrome (BRCA1/BRCA2) mutations. It is unknown if this association is causal. EXPERIMENTAL DESIGN This is a single-site study of patients who underwent surgical pancreatic tumor resection and self-identified as Ashkenazi Jewish. DNA from normal pancreatic tissue was genotyped for the three Ashkenazi ...
متن کاملBRCA1/2 mutation screening and LOH analysis of lung adenocarcinoma tissue in a multiple-cancer patient with a strong family history of breast cancer
BACKGROUND: Germline mutations in BRCA1/2 greatly elevate risks of breast and ovarian cancers, but the role of these genes in tumourigenesis of other cancer types is still being investigated. OBJECTIVE: We report on an investigation of BRCA1/2 mutations and their loss of heterozygosity (LOH) in a patient with a strong family history of breast cancer who was diagnosed with consecutive primary ce...
متن کاملGermline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas.
Germline mutations in BRCA2 predispose carriers to the development of breast, ovarian, and a variety of other cancers. The original localization of the BRCA2 gene was aided by its homozygous deletion in a pancreatic carcinoma; indeed, an excess of pancreatic carcinoma has been seen in some BRCA2 cancer families. To determine the involvement of BRCA2 in pancreatic carcinomas, we screened for BRC...
متن کاملThe importance of BRCA1 and BRCA2 genes mutations in breast cancer development
Many factors including genetic, environmental, and acquired are involved in breast cancer development across various societies. Among all of these factors in families with a history of breast cancer throughout several generations, genetics, like predisposing genes to develop this disease, should be considered more. Early detection of mutation carriers in these genes, in turn, can play an import...
متن کاملPrevalence and clinical significance of BRCA1/2 germline and somatic mutations in Taiwanese patients with ovarian cancer
Germline and somatic BRCA1/2 mutations define a subset of patients with ovarian cancer who may benefit from treatment with poly (ADP-ribose) polymerase inhibitors. Unfortunately, data on the frequency of BRCA1/2 germline mutations in Taiwanese patients with ovarian cancer are scarce, with the prevalence of somatic mutations being unknown. We aim to investigate the occurrence of BRCA1/2 mutation...
متن کامل